CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria
نویسندگان
چکیده
منابع مشابه
Chromatin-level regulation of biosynthetic gene clusters.
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B. Modification of the chromatin landscape in fungal second...
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ژورنال
عنوان ژورنال: Nature Microbiology
سال: 2019
ISSN: 2058-5276
DOI: 10.1038/s41564-019-0573-8